Drug candidates are often biotransformed to reactive, toxic metabolites which damages DNA by peroxidase activity of COX-2. Comet and OxyDNA assays detect broken and oxygenated DNAs, respectively. However, thousands of different kinds of DNA adducts formed by drug candidates cannot be detected using the methods. Detroit R&D developed a long quantitative PCR (LQPCR) assays to detect DNA damage induced by thousands of different drug candidates. Our assays include Chemiluminescent Quantitative PCR (QPCR) kit and Real-Time PCR DNA Quantitation kit as well as human DNA damage repair-deficient/-proficient cell lines (XPA) expressing human COX-2. Those kits and cell lines can be used to measure DNA damage for academic researches and for industry in-vitro and in-vivo toxicology assays.